Alternative RNA splicing tied to schizophrenia-like behaviors in animal models

In a new study, Chinese researchers have discovered the previously unrecognized role of alternative splicing of the DOC2A ...
JSTOR Daily

Identification of transient intermediates during spliceosome activation by single molecule fluorescence microscopy

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 48 (November 29, 2022), pp. 1-12 (12 pages) Spliceosome activation is the process of creating the ...
BioWorld

Vigeneron’s mRNA trans-splicing gene therapy for Stargardt disease receives IND clearance

Vigeneron GmbH has received IND approval from the FDA for VG-801, a novel mRNA trans-splicing gene therapy to treat Stargardt disease and other retinal dystrophies associated with mutations in the ...
News Medical

LUC7 proteins play crucial role in efficient RNA splicing

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns, are cut ...
BioWorld

RNA-targeting CRISPR-Cas13 and engineered U1 correct variants in Stargardt disease

Disruption of alternative splicing can generate abnormal mRNA variants, producing nonfunctional proteins or triggering ...
RealClearScience

How Cells Avoid Errors When Manufacturing mRNA

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Health And Pharma

Rewiring RNA: Antisense RNA Therapy Exposes a New Weakness in Pancreatic Cancer

Researchers at CSH Laboratory identified an oncogenic SRSF1–AURKA–MYC circuit driving pancreatic ductal adenocarcinoma.
GEN

First Spliceosome Blueprint Reveals Complex Interplay, Uncovers Drug Targets

Researchers at the Centre for Genomic Regulation (CRG) have created the first blueprint of the human spliceosome, the complex molecular machine that edits genetic messages transcribed from DNA, ...